Resident Evil Requiem: The Overall Story Before the Events of the Game (Part 2)

Following the destruction of Raccoon City, the fight against biological weapons has now erupted worldwide, drawing in numerous parties with diverse objectives.

 

The global fight against bioterrorism

Following this event, Umbrella gradually collapsed, but bioterrorism continued to spread. In Resident Evil – Code: Veronica, Claire is kidnapped by Umbrella and imprisoned in a secret prison. She manages to escape just before Chris  arrives, and he discovers she is still alive. Umbrella is even trying to steal a variant of the  T-Veronica virus .  Chris  rescues  Claire  in Antarctica but  Wesker  manages to escape.

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The story jumps to 2004, when Leon Kennedy  is now a U.S. government agent. He's tasked with rescuing the President's daughter from a village in Spain. There, he discovers the villagers are infected with a parasite called  Las Plagas , and he reunites with  Ada Wong,  who is collecting samples of the virus to bring back to  Wesker .

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Ultimately, although both  Ashley  and  Leon were infected with the Las Plagas   parasite  , they were later vaccinated and returned to safety. In 2009,  Chris Redfield, then a member of the BSSA (  Biological Terrorism Service  ) , was investigating a biological weapons trafficking case in Africa with his new partner,  Sheva Alomar . There, local people were infected with a new variant of  Las Plagas , derived from the Progenitor  virus , which is produced through a flower called  Stailway of the Sun.

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It is also here that  Chris  discovers  Jill  is still alive but mind-controlled by  Wesker . He is collaborating with the  Tricel Corporation, Umbrella  's rival  , to spread a variant of the  Uroboros virus.  Ultimately, Chris rescues Jill and defeats Wesker, thus ending yet another bioterrorist plot. In  Resident Evil 6,  the world faces another pandemic involving  the C-Virus , the next variant of  the Progenitor Virus , created by the villainous organization  Neo-Umbrella.

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From here, a large-scale conflict erupts across the globe, involving many familiar figures such as Leon S. Kennedy, Chris Redfield, Ada , and many others. After a series of complex events, the forces of good ultimately prevail, and each character continues on their own path. Most importantly, Chris Redfield continues to serve in the BSAA , maintaining his role in the fight against bioterrorism.

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The story of Ethan Winters and Megamycete

In  Resident Evil 7: Biohazard,  fans are introduced to a new character, Ethan. He travels to the  Baker family ranch  in  Louisiana  to search for his wife,  Mia Winters , after receiving a video from her. Upon arriving, he discovers that the  Baker family  has been transformed into strange, bloodthirsty creatures. Through a series of events,  Ethan  uncovers the truth: it all stems from  Eveline , a bioweapon created by  The Connection , the organization where  Mia  secretly works.

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Ethan  and  Mia  are later rescued by  Chris Redfield  and the BSAA  but this time working for  the Umbrella Corporation an organization formed after  Umbrella's downfall  to deal with its aftermath   . Things escalate three years later, when  Chris  unexpectedly appears at  Ethan's house,  shoots Mia  dead  , and then kidnaps him and his daughter,  Rosemary . An accident occurs,  Rosemary  disappears, and as  Ethan  follows her trail, he arrives at a mysterious village.

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Here, all the mysteries gradually unfold:  Mia  , whom  Chris  shot and killed at the beginning of the game, was actually an imposter. She was initially just a mother who lost her child after the Spanish flu pandemic, but she accidentally discovered the ancient mold entity  Megamycete . From there, she became Spencer 's mentor   in founding  Umbrella  and creating the viruses that followed. Finally,  Ethan  saves  Rosemary,  but only then is the truth revealed:  Ethan had actually died while still at the Baker  family farm  . His body was regenerated thanks to  Eveline 's mold .

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In the end,  Ethan  sacrifices himself to prevent  the Megamycete  from spreading globally, while  Chris Redfield  returns to  the BSAA  to investigate the incident where his soldiers were turned into biological weapons. He also helps the girl become a BSAA agent,  and in another storyline, she is reunited with her father, albeit briefly.

Step into Resident Evil Requiem

All these events lead to Resident Evil Requiem, when  Leon S. Kennedy  returns to  Raccoon City  to investigate the debilitating illness affecting survivors of the events of the past. At the same time,  Grace Ashcroft, the daughter of journalist Alyssa Ashcroft,  is also kidnapped and brought to the city. 

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The two met to continue opening a new chapter in the fight against biological weapons, while simultaneously bringing to a close a story spanning nearly 30 years after the zombie pandemic first broke out.

Update 26 March 2026

Kareem Winters

Kareem Winters is an AI integration expert, a strategic process of embedding artificial intelligence technologies—such as machine learning (ML), natural language processing (NLP), and computer vision—directly into an organization's existing systems, applications, and workflows.

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